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Next-generation matrix : ウィキペディア英語版
Next-generation matrix
In epidemiology, the next-generation matrix is a method used to derive the basic reproduction number, for a compartmental model of the spread of infectious diseases. This method is given by Diekmann ''et al.'' (1990) and van den Driessche and Watmough (2002). To calculate the basic reproduction number by using a next-generation matrix, the whole population is divided into n compartments in which there are m infected compartments. Let x_i, i=1,2,3,\ldots,m be the numbers of infected individuals in the i^ infected compartment at time ''t''. Now, the epidemic model is
: \frac= F_i (x)-V_i(x), where V_i(x)= ()
In the above equations, F_i(x) represents the rate of appearance of new infections in compartment i . V^+_i represents the rate of transfer of individuals into compartment i by all other means, and V^-_i (x) represents the rate of transfer of individuals out of compartment i .
The above model can also be written as
: \frac= F(x)-V(x)
where
: F(x) = \begin
F_1(x), & F_2(x), & \ldots, & F_n(x)
\end^T
and
: V(x) = \begin
V_1(x), & V_2 (x), & \ldots, & V_n(x)
\end^T.
Let x_0 be the disease-free equilibrium. The values of the Jacobian matrices F(x) and V(x) are:
: DF(x_0) = \begin
F & 0 \\
0 & 0
\end
and
:
DV(x_0) = \begin
V & 0 \\
J_3 & J_4
\end
respectively.
Here, F and V are ''m'' × ''m'' matrices, defined as
F= \frac(x_0) and V=\frac(x_0) .
Now, the matrix FV^ is known as the next-generation matrix. The largest eigenvalue or spectral radius of FV^ is the basic reproduction number of the model.
==See also==

*Mathematical modelling of infectious disease

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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